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- Title
betaAR signaling required for diet-induced thermogenesis and obesity resistance.
- Authors
Bachman, Eric S; Dhillon, Harveen; Zhang, Chen-Yu; Cinti, Saverio; Bianco, Antonio C; Kobilka, Brian K; Lowell, Bradford B
- Abstract
Excessive caloric intake is thought to be sensed by the brain, which then activates thermogenesis as a means of preventing obesity. The sympathetic nervous system, through beta-adrenergic receptor (betaAR) action on target tissues, is likely the efferent arm of this homeostatic mechanism. To test this hypothesis, we created mice that lack the three known betaARs (beta-less mice). beta-less mice on a Chow diet had a reduced metabolic rate and were slightly obese. On a high-fat diet, beta-less mice, in contrast to wild-type mice, developed massive obesity that was due entirely to a failure of diet-induced thermogenesis. These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity.
- Publication
Science (New York, N.Y.), 2002, Vol 297, Issue 5582, p843
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1073160