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- Title
Distinct modes of signal recognition particle interaction with the ribosome.
- Authors
Pool, Martin R; Stumm, Joachim; Fulga, Tudor A; Sinning, Irmgard; Dobberstein, Bernhard
- Abstract
Signal recognition particle (SRP), together with its receptor (SR), mediates the targeting of ribosome-nascent chain complexes to the endoplasmic reticulum. Using protein cross-linking, we detected distinct modes in the binding of SRP to the ribosome. During signal peptide recognition, SRP54 is positioned at the exit site close to ribosomal proteins L23a and L35. When SRP54 contacts SR, SRP54 is rearranged such that it is no longer close to L23a. This repositioning may allow the translocon to dock with the ribosome, leading to insertion of the signal peptide into the translocation channel.
- Publication
Science (New York, N.Y.), 2002, Vol 297, Issue 5585, p1345
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1072366