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- Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
- Authors
Liu, Wen; Christenson, Steven D; Standage, Scott; Shen, Ben
- Abstract
C-1027 is a potent antitumor agent with a previously undescribed molecular architecture and mode of action. Cloning and characterization of the 85-kilobase C-1027 biosynthesis gene cluster from Streptomyces globisporus revealed (i) an iterative type I polyketide synthase that is distinct from any bacterial polyketide synthases known to date, (ii) a general polyketide pathway for the biosynthesis of both the 9- and 10-membered enediyne antibiotics, and (iii) a convergent biosynthetic strategy for the C-1027 chromophore from four building blocks. Manipulation of genes governing C-1027 biosynthesis allowed us to produce an enediyne compound in a predicted manner.
- Publication
Science (New York, N.Y.), 2002, Vol 297, Issue 5584, p1170
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1072110