We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis.
- Authors
Read, Timothy D; Salzberg, Steven L; Pop, Mihai; Shumway, Martin; Umayam, Lowell; Jiang, Lingxia; Holtzapple, Erik; Busch, Joseph D; Smith, Kimothy L; Schupp, James M; Solomon, Daniel; Keim, Paul; Fraser, Claire M
- Abstract
Comparison of the whole-genome sequence of Bacillus anthracis isolated from a victim of a recent bioterrorist anthrax attack with a reference reveals 60 new markers that include single nucleotide polymorphisms (SNPs), inserted or deleted sequences, and tandem repeats. Genome comparison detected four high-quality SNPs between the two sequenced B. anthracis chromosomes and seven differences among different preparations of the reference genome. These markers have been tested on a collection of anthrax isolates and were found to divide these samples into distinct families. These results demonstrate that genome-based analysis of microbial pathogens will provide a powerful new tool for investigation of infectious disease outbreaks.
- Publication
Science (New York, N.Y.), 2002, Vol 296, Issue 5575, p2028
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1071837