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- Title
Activation of endothelial cell protease activated receptor 1 by the protein C pathway.
- Authors
Riewald, Matthias; Petrovan, Ramona J; Donner, Aaron; Mueller, Barbara M; Ruf, Wolfram
- Abstract
The coagulant and inflammatory exacerbation in sepsis is counterbalanced by the protective protein C (PC) pathway. Activated PC (APC) was shown to use the endothelial cell PC receptor (EPCR) as a coreceptor for cleavage of protease activated receptor 1 (PAR1) on endothelial cells. Gene profiling demonstrated that PAR1 signaling could account for all APC-induced protective genes, including the immunomodulatory monocyte chemoattractant protein-1 (MCP-1), which was selectively induced by activation of PAR1, but not PAR2. Thus, the prototypical thrombin receptor is the target for EPCR-dependent APC signaling, suggesting a role for this receptor cascade in protection from sepsis.
- Publication
Science (New York, N.Y.), 2002, Vol 296, Issue 5574, p1880
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1071699