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- Title
G protein pathways.
- Authors
Neves, Susana R; Ram, Prahlad T; Iyengar, Ravi
- Abstract
The heterotrimeric guanine nucleotide-binding proteins (G proteins) are signal transducers that communicate signals from many hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. The extracellular signals are received by members of a large superfamily of receptors with seven membrane-spanning regions that activate the G proteins, which route the signals to several distinct intracellular signaling pathways. These pathways interact with one another to form a network that regulates metabolic enzymes, ion channels, transporters, and other components of the cellular machinery controlling a broad range of cellular processes, including transcription, motility, contractility, and secretion. These cellular processes in turn regulate systemic functions such as embryonic development, gonadal development, learning and memory, and organismal homeostasis.
- Publication
Science (New York, N.Y.), 2002, Vol 296, Issue 5573, p1636
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1071550