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- Title
Identification of signal peptide peptidase, a presenilin-type aspartic protease.
- Authors
Weihofen, Andreas; Binns, Kathleen; Lemberg, Marius K; Ashman, Keith; Martoglio, Bruno
- Abstract
Signal peptide peptidase (SPP) catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. In humans, SPP activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. We have identified human SPP as a polytopic membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. SPP and potential eukaryotic homologs may represent another family of aspartic proteases that promote intramembrane proteolysis to release biologically important peptides.
- Publication
Science (New York, N.Y.), 2002, Vol 296, Issue 5576, p2215
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1070925