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- Title
Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila.
- Authors
Choe, Kwang-Min; Werner, Thomas; Stöven, Svenja; Hultmark, Dan; Anderson, Kathryn V
- Abstract
Components of microbial cell walls are potent activators of innate immune responses in animals. For example, the mammalian TLR4 signaling pathway is activated by bacterial lipopolysaccharide and is required for resistance to infection by Gram-negative bacteria. Other components of microbial surfaces, such as peptidoglycan, are also potent activators of innate immune responses, but less is known about how those components activate host defense. Here we show that a peptidoglycan recognition protein, PGRP-LC, is absolutely required for the induction of antibacterial peptide genes in response to infection in Drosophila and acts by controlling activation of the NF-kappaB family transcription factor Relish.
- Publication
Science (New York, N.Y.), 2002, Vol 296, Issue 5566, p359
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1070216