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- Title
Germline stem cells anchored by adherens junctions in the Drosophila ovary niches.
- Authors
Song, Xiaoqing; Zhu, Chun-Hong; Doan, Chuong; Xie, Ting
- Abstract
How stem cells are recruited to and maintained in their niches is crucial to understanding their regulation and use in regenerative medicine. Here, we demonstrate that DE-cadherin-mediated cell adhesion is required for anchoring germline stem cells (GSCs) in their niches in the Drosophila ovary. Two major components of this adhesion process, DE-cadherin and Armadillo/beta-catenin, accumulate at high levels in the junctions between GSCs and cap cells, one of the niche components. Removal of these proteins from GSCs results in stem cell loss. Furthermore, DE-cadherin is required for recruiting GSCs to their niche. Our study demonstrates that anchorage of GSCs in their niche by DE-cadherin-mediated adhesion is important for stem cell maintenance and function.
- Publication
Science (New York, N.Y.), 2002, Vol 296, Issue 5574, p1855
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1069871