We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evidence of HIV-1 adaptation to HLA-restricted immune responses at a population level.
- Authors
Moore, Corey B; John, Mina; James, Ian R; Christiansen, Frank T; Witt, Campbell S; Mallal, Simon A
- Abstract
Antigen-specific T cell immunity is HLA-restricted. Human immunodeficiency virus-type 1 (HIV-1) mutations that allow escape from host immune responses may therefore be HLA allele-specific. We analyzed HIV-1 reverse transcriptase sequences from a large HLA-diverse population of HIV-1-infected individuals. Polymorphisms in HIV-1 were most evident at sites of least functional or structural constraint and frequently were associated with particular host HLA class I alleles. Absence of polymorphism was also HLA allele-specific. At a population level, the degree of HLA-associated selection in viral sequence was predictive of viral load. These results support a fundamental role for HLA-restricted immune responses in driving and shaping HIV-1 evolution in vivo.
- Publication
Science (New York, N.Y.), 2002, Vol 296, Issue 5572, p1439
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1069660