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- Title
A role for lipid shells in targeting proteins to caveolae, rafts, and other lipid domains.
- Authors
Anderson, Richard G W; Jacobson, Ken
- Abstract
The surface membrane of cells is studded with morphologically distinct regions, or domains, like microvilli, cell-cell junctions, and coated pits. Each of these domains is specialized for a particular function, such as nutrient absorption, cell-cell communication, and endocytosis. Lipid domains, which include caveolae and rafts, are one of the least understood membrane domains. These domains are high in cholesterol and sphingolipids, have a light buoyant density, and function in both endocytosis and cell signaling. A major mystery, however, is how resident molecules are targeted to lipid domains. Here, we propose that the molecular address for proteins targeted to lipid domains is a lipid shell.
- Publication
Science (New York, N.Y.), 2002, Vol 296, Issue 5574, p1821
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1068886