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- Title
Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.
- Authors
Lai, Liangxue; Kolber-Simonds, Donna; Park, Kwang-Wook; Cheong, Hee-Tae; Greenstein, Julia L; Im, Gi-Sun; Samuel, Melissa; Bonk, Aaron; Rieke, August; Day, Billy N; Murphy, Clifton N; Carter, David B; Hawley, Robert J; Prather, Randall S
- Abstract
The presence of galactose alpha-1,3-galactose residues on the surface of pig cells is a major obstacle to successful xenotransplantation. Here, we report the production of four live pigs in which one allele of the alpha-1,3-galactosyltransferase locus has been knocked out. These pigs were produced by nuclear transfer technology; clonal fetal fibroblast cell lines were used as nuclear donors for embryos reconstructed with enucleated pig oocytes.
- Publication
Science (New York, N.Y.), 2002, Vol 295, Issue 5557, p1089
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1068228