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- Title
Signaling life and death in the thymus: timing is everything.
- Authors
Werlen, Guy; Hausmann, Barbara; Naeher, Dieter; Palmer, Ed
- Abstract
T lymphocytes are generated in the thymus, where developing thymocytes must accept one of two fates: They either differentiate or they die. These fates are chiefly determined by signals that originate from the T cell receptor (TCR), a single receptor complex with a remarkable capacity to decide between distinct cell fates. This review explores TCR signaling in thymocytes and focuses on the kinetic aspects of ligand binding, coreceptor involvement, protein phosphorylation, and mitogen-activated protein kinase (MAPK) activation. Understanding the logic of TCR signaling may eventually explain how thymocytes and T cells distinguish self from nonself, a phenomenon that has fascinated immunologists for 50 years.
- Publication
Science (New York, N.Y.), 2003, Vol 299, Issue 5614, p1859
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1067833