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- Title
Postsynaptic Induction of BDNF-Mediated Long-Term Potentiation.
- Authors
Kovalchuk, Yury; Hanse, Eric; Kafitz, Karl W; Konnerth, Arthur
- Abstract
Brain-derived neurotrophic factor (BDNF) and other neurotrophins are critically involved in long-term potentiation (LTP). Previous reports point to a presynaptic site of neurotrophin action. By imaging dentate granule cells in mouse hippocampal slices, we identified BDNF-evoked Ca2+ transients in dendrites and spines, but not at presynaptic sites. Pairing a weak burst of synaptic stimulation with a brief dendritic BDNF application caused an immediate and robust induction of LTP. LTP induction required activation of postsynaptic Ca2+ channels and N-methyl-d-aspartate receptors and was prevented by the blockage of postsynaptic Ca2+ transients. Thus, our results suggest that BDNF-mediated LTP is induced postsynaptically. Our finding that dendritic spines are the exclusive synaptic sites for rapid BDNF-evoked Ca2+ signaling supports this conclusion.
- Publication
Science (New York, N.Y.), 2002, Vol 295, Issue 5560, p1729
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1067766