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- Title
Reverse transcriptase-mediated tropism switching in Bordetella bacteriophage.
- Authors
Liu, Minghsun; Deora, Rajendar; Doulatov, Sergei R; Gingery, Mari; Eiserling, Frederick A; Preston, Andrew; Maskell, Duncan J; Simons, Robert W; Cotter, Peggy A; Parkhill, Julian; Miller, Jeff F
- Abstract
Host-pathogen interactions are often driven by mechanisms that promote genetic variability. We have identified a group of temperate bacteriophages that generate diversity in a gene, designated mtd (major tropism determinant), which specifies tropism for receptor molecules on host Bordetella species. Tropism switching is the result of a template-dependent, reverse transcriptase-mediated process that introduces nucleotide substitutions at defined locations within mtd. This cassette-based mechanism is capable of providing a vast repertoire of potential ligand-receptor interactions.
- Publication
Science (New York, N.Y.), 2002, Vol 295, Issue 5562, p2091
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1067467