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- Title
Placebo and opioid analgesia-- imaging a shared neuronal network.
- Authors
Petrovic, Predrag; Kalso, Eija; Petersson, Karl Magnus; Ingvar, Martin
- Abstract
It has been suggested that placebo analgesia involves both higher order cognitive networks and endogenous opioid systems. The rostral anterior cingulate cortex (rACC) and the brainstem are implicated in opioid analgesia, suggesting a similar role for these structures in placebo analgesia. Using positron emission tomography, we confirmed that both opioid and placebo analgesia are associated with increased activity in the rACC. We also observed a covariation between the activity in the rACC and the brainstem during both opioid and placebo analgesia, but not during the pain-only condition. These findings indicate a related neural mechanism in placebo and opioid analgesia.
- Publication
Science (New York, N.Y.), 2002, Vol 295, Issue 5560, p1737
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1067176