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- Title
Protein nanoarrays generated by dip-pen nanolithography.
- Authors
Lee, Ki-Bum; Park, So-Jung; Mirkin, Chad A; Smith, Jennifer C; Mrksich, Milan
- Abstract
Dip-pen nanolithography was used to construct arrays of proteins with 100- to 350-nanometer features. These nanoarrays exhibit almost no detectable nonspecific binding of proteins to their passivated portions even in complex mixtures of proteins, and therefore provide the opportunity to study a variety of surface-mediated biological recognition processes. For example, reactions involving the protein features and antigens in complex solutions can be screened easily by atomic force microscopy. As further proof-of-concept, these arrays were used to study cellular adhesion at the submicrometer scale.
- Publication
Science (New York, N.Y.), 2002, Vol 295, Issue 5560, p1702
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1067172