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- Title
KLF6, a candidate tumor suppressor gene mutated in prostate cancer.
- Authors
Narla, G; Heath, K E; Reeves, H L; Li, D; Giono, L E; Kimmelman, A C; Glucksman, M J; Narla, J; Eng, F J; Chan, A M; Ferrari, A C; Martignetti, J A; Friedman, S L
- Abstract
Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6 allele is deleted in 77% (17 of 22) of primary prostate tumors. Sequence analysis of the retained KLF6 allele revealed mutations in 71% of these tumors. Functional studies confirm that whereas wild-type KLF6 up-regulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation, tumor-derived KLF6 mutants do not. Our data suggest that KLF6 is a tumor suppressor gene involved in human prostate cancer.
- Publication
Science (New York, N.Y.), 2001, Vol 294, Issue 5551, p2563
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1066326