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- Title
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet.
- Authors
Finotto, Susetta; Neurath, Markus F; Glickman, Jonathan N; Qin, Shixin; Lehr, Hans A; Green, Francis H Y; Ackerman, Kate; Haley, Kathleen; Galle, Peter R; Szabo, Susanne J; Drazen, Jeffrey M; De Sanctis, George T; Glimcher, Laurie H
- Abstract
Human asthma is associated with airway infiltration by T helper 2 (TH2) lymphocytes. We observed reduced expression of the TH1 transcription factor, T-bet, in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of T-bet might be associated with asthma. Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+ cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma. Thus, T-bet deficiency, in the absence of allergen exposure, induces a murine phenotype reminiscent of both acute and chronic human asthma.
- Publication
Science (New York, N.Y.), 2002, Vol 295, Issue 5553, p336
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.1065544