We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Induction of pancreatic differentiation by signals from blood vessels.
- Authors
Lammert, E; Cleaver, O; Melton, D
- Abstract
Blood vessels supply developing organs with metabolic sustenance. Here, we demonstrate a role for blood vessels as a source of developmental signals during pancreatic organogenesis. In vitro experiments with embryonic mouse tissues demonstrate that blood vessel endothelium induces insulin expression in isolated endoderm. Removal of the dorsal aorta in Xenopus laevis embryos results in the failure of insulin expression in vivo. Furthermore, using transgenic mice, we show that ectopic vascularization in the posterior foregut leads to ectopic insulin expression and islet hyperplasia. These results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development.
- Publication
Science (New York, N.Y.), 2001, Vol 294, Issue 5542, p564
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1064344