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- Title
Tumor therapy with targeted atomic nanogenerators.
- Authors
McDevitt, M R; Ma, D; Lai, L T; Simon, J; Borchardt, P; Frank, R K; Wu, K; Pellegrini, V; Curcio, M J; Miederer, M; Bander, N H; Scheinberg, D A
- Abstract
A single, high linear energy transfer alpha particle can kill a target cell. We have developed methods to target molecular-sized generators of alpha-emitting isotope cascades to the inside of cancer cells using actinium-225 coupled to internalizing monoclonal antibodies. In vitro, these constructs specifically killed leukemia, lymphoma, breast, ovarian, neuroblastoma, and prostate cancer cells at becquerel (picocurie) levels. Injection of single doses of the constructs at kilobecquerel (nanocurie) levels into mice bearing solid prostate carcinoma or disseminated human lymphoma induced tumor regression and prolonged survival, without toxicity, in a substantial fraction of animals. Nanogenerators targeting a wide variety of cancers may be possible.
- Publication
Science (New York, N.Y.), 2001, Vol 294, Issue 5546, p1537
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1064126