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- Title
The centromere paradox: stable inheritance with rapidly evolving DNA.
- Authors
Henikoff, S; Ahmad, K; Malik, H S
- Abstract
Every eukaryotic chromosome has a centromere, the locus responsible for poleward movement at mitosis and meiosis. Although conventional loci are specified by their DNA sequences, current evidence favors a chromatin-based inheritance mechanism for centromeres. The chromosome segregation machinery is highly conserved across all eukaryotes, but the DNA and protein components specific to centromeric chromatin are evolving rapidly. Incompatibilities between rapidly evolving centromeric components may be responsible for both the organization of centromeric regions and the reproductive isolation of emerging species.
- Publication
Science (New York, N.Y.), 2001, Vol 293, Issue 5532, p1098
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1062939