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- Title
Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses.
- Authors
Hatta, M; Gao, P; Halfmann, P; Kawaoka, Y
- Abstract
In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.
- Publication
Science (New York, N.Y.), 2001, Vol 293, Issue 5536, p1840
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1062882