We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.
- Authors
Senftleben, U; Cao, Y; Xiao, G; Greten, F R; Krähn, G; Bonizzi, G; Chen, Y; Hu, Y; Fong, A; Sun, S C; Karin, M
- Abstract
In mammals, the canonical nuclear factor kappaB (NF-kappaB) signaling pathway activated in response to infections is based on degradation of IkappaB inhibitors. This pathway depends on the IkappaB kinase (IKK), which contains two catalytic subunits, IKKalpha and IKKbeta. IKKbeta is essential for inducible IkappaB phosphorylation and degradation, whereas IKKalpha is not. Here we show that IKKalpha is required for B cell maturation, formation of secondary lymphoid organs, increased expression of certain NF-kappaB target genes, and processing of the NF-kappaB2 (p100) precursor. IKKalpha preferentially phosphorylates NF-kappaB2, and this activity requires its phosphorylation by upstream kinases, one of which may be NF-kappaB-inducing kinase (NIK). IKKalpha is therefore a pivotal component of a second NF-kappaB activation pathway based on regulated NF-kappaB2 processing rather than IkappaB degradation.
- Publication
Science (New York, N.Y.), 2001, Vol 293, Issue 5534, p1495
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1062677