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- Title
Patterns of gene expression during Drosophila mesoderm development.
- Authors
Furlong, E E; Andersen, E C; Null, B; White, K P; Scott, M P
- Abstract
The transcription factor Twist initiates Drosophila mesoderm development, resulting in the formation of heart, somatic muscle, and other cell types. Using a Drosophila embryo sorter, we isolated enough homozygous twist mutant embryos to perform DNA microarray experiments. Transcription profiles of twist loss-of-function embryos, embryos with ubiquitous twist expression, and wild-type embryos were compared at different developmental stages. The results implicate hundreds of genes, many with vertebrate homologs, in stage-specific processes in mesoderm development. One such gene, gleeful, related to the vertebrate Gli genes, is essential for somatic muscle development and sufficient to cause neural cells to express a muscle marker.
- Publication
Science (New York, N.Y.), 2001, Vol 293, Issue 5535, p1629
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1062660