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- Title
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.
- Authors
Puthalakath, H; Villunger, A; O'Reilly, L A; Beaumont, J G; Coultas, L; Cheney, R E; Huang, D C; Strasser, A
- Abstract
Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In healthy cells, Bmf is sequestered to myosin V motors by association with dynein light chain 2. Certain damage signals, such as loss of cell attachment (anoikis), unleash Bmf, allowing it to translocate and bind prosurvival Bcl-2 proteins. Thus, at least two mammalian BH3-only proteins, Bmf and Bim, function to sense intracellular damage by their localization to distinct cytoskeletal structures.
- Publication
Science (New York, N.Y.), 2001, Vol 293, Issue 5536, p1829
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1062257