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- Title
BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.
- Authors
Thompson, J S; Bixler, S A; Qian, F; Vora, K; Scott, M L; Cachero, T G; Hession, C; Schneider, P; Sizing, I D; Mullen, C; Strauch, K; Zafari, M; Benjamin, C D; Tschopp, J; Browning, J L; Ambrose, C
- Abstract
B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.
- Publication
Science (New York, N.Y.), 2001, Vol 293, Issue 5537, p2108
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1061965