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- Title
Role of inorganic polyphosphate in promoting ribosomal protein degradation by the Lon protease in E. coli.
- Authors
Kuroda, A; Nomura, K; Ohtomo, R; Kato, J; Ikeda, T; Takiguchi, N; Ohtake, H; Kornberg, A
- Abstract
Inorganic polyphosphate (polyP), a polymer of hundreds of phosphate (Pi) residues, accumulates in Escherichia coli in response to stresses, including amino acid starvation. Here we show that the adenosine 5'-triphosphate-dependent protease Lon formed a complex with polyP and degraded most of the ribosomal proteins, including S2, L9, and L13. Purified S2 also bound to polyP and formed a complex with Lon in the presence of polyP. Thus, polyP may promote ribosomal protein degradation by the Lon protease, thereby supplying the amino acids needed to respond to starvation.
- Publication
Science (New York, N.Y.), 2001, Vol 293, Issue 5530, p705
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1061315