We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons.
- Authors
Wei, D S; Mei, Y A; Bagal, A; Kao, J P; Thompson, S M; Tang, C M
- Abstract
The dendritic arbor of pyramidal neurons is not a monolithic structure. We show here that the excitability of terminal apical dendrites differs from that of the apical trunk. In response to fluorescence-guided focal photolysis of caged glutamate, individual terminal apical dendrites generated cadmium-sensitive all-or-none responses that were subthreshold for somatic action potentials. Calcium transients produced by all-or-none responses were not restricted to the sites of photolysis, but occurred throughout individual distal dendritic compartments, indicating that electrogenesis is mediated primarily by voltage-gated calcium channels. Compartmentalized and binary behavior of parallel-connected terminal dendrites can greatly expand the computational power of a single neuron.
- Publication
Science (New York, N.Y.), 2001, Vol 293, Issue 5538, p2272
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1061198