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- Title
Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation.
- Authors
Dupuis, S; Dargemont, C; Fieschi, C; Thomassin, N; Rosenzweig, S; Harris, J; Holland, S M; Schreiber, R D; Casanova, J L
- Abstract
Interferons (IFN) alpha/beta and gamma induce the formation of two transcriptional activators: gamma-activating factor (GAF) and interferon-stimulated gamma factor 3 (ISGF3). We report a natural heterozygous germline STAT1 mutation associated with susceptibility to mycobacterial but not viral disease. This mutation causes a loss of GAF and ISGF3 activation but is dominant for one cellular phenotype and recessive for the other. It impairs the nuclear accumulation of GAF but not of ISGF3 in heterozygous cells stimulated by IFNs. Thus, the antimycobacterial, but not the antiviral, effects of human IFNs are principally mediated by GAF.
- Publication
Science (New York, N.Y.), 2001, Vol 293, Issue 5528, p300
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1061154