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- Title
Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor.
- Authors
Zhu, Y; Doray, B; Poussu, A; Lehto, V P; Kornfeld, S
- Abstract
The GGAs are a multidomain protein family implicated in protein trafficking between the Golgi and endosomes. Here, the VHS domain of GGA2 was shown to bind to the acidic cluster-dileucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR). Receptors with mutations in this motif were defective in lysosomal enzyme sorting. The hinge domain of GGA2 bound clathrin, suggesting that GGA2 could be a link between cargo molecules and clathrin-coated vesicle assembly. Thus, GGA2 binding to the CI-MPR is important for lysosomal enzyme targeting.
- Publication
Science (New York, N.Y.), 2001, Vol 292, Issue 5522, p1716
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1060896