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- Title
Sorting of mannose 6-phosphate receptors mediated by the GGAs.
- Authors
Puertollano, R; Aguilar, R C; Gorshkova, I; Crouch, R J; Bonifacino, J S
- Abstract
The delivery of soluble hydrolases to lysosomes is mediated by the cation-independent and cation-dependent mannose 6-phosphate receptors. The cytosolic tails of both receptors contain acidic-cluster-dileucine signals that direct sorting from the trans-Golgi network to the endosomal-lysosomal system. We found that these signals bind to the VHS domain of the Golgi-localized, gamma-ear-containing, ARF-binding proteins (GGAs). The receptors and the GGAs left the trans-Golgi network on the same tubulo-vesicular carriers. A dominant-negative GGA mutant blocked exit of the receptors from the trans-Golgi network. Thus, the GGAs appear to mediate sorting of the mannose 6-phosphate receptors at the trans-Golgi network.
- Publication
Science (New York, N.Y.), 2001, Vol 292, Issue 5522, p1712
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1060750