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- Title
Dendrodendritic inhibition through reversal of dopamine transport.
- Authors
Falkenburger, B H; Barstow, K L; Mintz, I M
- Abstract
Synapses in the central nervous system are usually defined by presynaptic exocytotic release sites and postsynaptic differentiations. We report here a demonstration of dendrodendritic inhibition that does not engage a conventional synapse. Using amperometric and patch-clamp recordings in rat brain slices of the substantia nigra, we found that blockade of the dopamine transporter abolished the dendritic release of dopamine and the resulting self-inhibition. These findings demonstrate that dendrodendritic autoinhibition entails the carrier-mediated release of dopamine rather than conventional exocytosis. This suggests that some widely used antidepressants that inhibit the dopamine transporter may benefit patients in the early stages of Parkinson's disease.
- Publication
Science (New York, N.Y.), 2001, Vol 293, Issue 5539, p2465
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1060645