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- Title
A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier.
- Authors
Lecuit, M; Vandormael-Pournin, S; Lefort, J; Huerre, M; Gounon, P; Dupuy, C; Babinet, C; Cossart, P
- Abstract
Listeria monocytogenes is responsible for severe food-borne infections, but the mechanisms by which bacteria cross the intestinal barrier are unknown. Listeria monocytogenes expresses a surface protein, internalin, that interacts with a host receptor, E-cadherin, to promote entry into human epithelial cells. Murine E-cadherin, in contrast to guinea pig E-cadherin, does not interact with internalin, excluding the mouse as a model for addressing internalin function in vivo. In guinea pigs and transgenic mice expressing human E-cadherin, internalin was found to mediate invasion of enterocytes and crossing of the intestinal barrier. These results illustrate how relevant animal models for human infections can be generated.
- Publication
Science (New York, N.Y.), 2001, Vol 292, Issue 5522, p1722
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1059852