We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Glycoprotein structure determination by mass spectrometry.
- Authors
Dell, A; Morris, H R
- Abstract
The human genome encodes 30,000 to 40,000 proteins, and a major challenge is to understand how posttranslational events, such as glycosylation, affect the activities and functions of these proteins in health and disease. Glycosylated proteins are ubiquitous components of extracellular matrices and cellular surfaces where their oligosaccharide moieties are implicated in a wide range of cell-cell and cell-matrix recognition events. The power of ultrahigh-sensitivity mass spectrometric strategies for defining the primary structures of highly complex mixtures of glycoprotein glycoforms is set to revolutionize structural glycobiology in the coming postgenomic era.
- Publication
Science (New York, N.Y.), 2001, Vol 291, Issue 5512, p2351
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1058890