We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.
- Authors
Cao, X; Südhof, T C
- Abstract
Amyloid-beta precursor protein (APP), a widely expressed cell-surface protein, is cleaved in the transmembrane region by gamma-secretase. gamma-Cleavage of APP produces the extracellular amyloid beta-peptide of Alzheimer's disease and releases an intracellular tail fragment of unknown physiological function. We now demonstrate that the cytoplasmic tail of APP forms a multimeric complex with the nuclear adaptor protein Fe65 and the histone acetyltransferase Tip60. This complex potently stimulates transcription via heterologous Gal4- or LexA-DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression.
- Publication
Science (New York, N.Y.), 2001, Vol 293, Issue 5527, p115
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1058783