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- Title
Genes lost and genes found: evolution of bacterial pathogenesis and symbiosis.
- Authors
Ochman, H; Moran, N A
- Abstract
Traditionally, evolutionary biologists have viewed mutations within individual genes as the major source of phenotypic variation leading to adaptation through natural selection, and ultimately generating diversity among species. Although such processes must contribute to the initial development of gene functions and their subsequent fine-tuning, changes in genome repertoire, occurring through gene acquisition and deletion, are the major events underlying the emergence and evolution of bacterial pathogens and symbionts. Furthermore, pathogens and symbionts depend on similar mechanisms for interacting with hosts and show parallel trends in genome evolution.
- Publication
Science (New York, N.Y.), 2001, Vol 292, Issue 5519, p1096
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1058543