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- Title
Relapse to cocaine-seeking after hippocampal theta burst stimulation.
- Authors
Vorel, S R; Liu, X; Hayes, R J; Spector, J A; Gardner, E L
- Abstract
Treatment efforts for cocaine addiction are hampered by high relapse rates. To map brain areas underlying relapse, we used electrical brain stimulation and intracranial injection of pharmacological compounds after extinction of cocaine self-administration behavior in rats. Electrical stimulation of the hippocampus containing glutamatergic fibers, but not the medial forebrain bundle containing dopaminergic fibers, elicited cocaine-seeking behavior dependent on glutamate in the ventral tegmental area. This suggests a role for glutamatergic neurotransmission in relapse to cocaine abuse. The medial forebrain bundle electrodes supported intense electrical self-stimulation. These findings suggest a dissociation of neural systems subserving positive reinforcement (self-stimulation) and incentive motivation (relapse).
- Publication
Science (New York, N.Y.), 2001, Vol 292, Issue 5519, p1175
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1058043