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- Title
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
- Authors
Clancy, D J; Gems, D; Harshman, L G; Oldham, S; Stocker, H; Hafen, E; Leevers, S J; Partridge, L
- Abstract
The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.
- Publication
Science (New York, N.Y.), 2001, Vol 292, Issue 5514, p104
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.1057991