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- Title
Improved signal processing to detect cancer by ultrasonic molecular imaging of targeted nanoparticles.
- Authors
Hughes, Michael; Marsh, Jon; Lanza, Gregory; Wickline, Samuel; McCarthy, John; Wickerhauser, Victor; Maurizi, Brian; Wallace, Kirk
- Abstract
In several investigations of molecular imaging of angiogenic neovasculature using a targeted contrast agent, Renyi entropy [I(f)(r)] and a limiting form of Renyi entropy (I(f,∞)) exhibited significantly more sensitivity to subtle changes in scattering architecture than energy-based methods. Many of these studies required the fitting of a cubic spline to backscattered waveforms prior to calculation of entropy [either I(f)(r) or I(f,∞)]. In this study, it is shown that the robustness of I(f,∞) may be improved by using a smoothing spline. Results are presented showing the impact of different smoothing parameters. In addition, if smoothing is preceded by low-pass filtering of the waveforms, further improvements may be obtained.
- Publication
The Journal of the Acoustical Society of America, 2011, Vol 129, Issue 6, p3756
- ISSN
1520-8524
- Publication type
Journal Article
- DOI
10.1121/1.3578459