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- Title
Potential of in vivo MRI-based nonlinear finite-element analysis for the assessment of trabecular bone post-yield properties.
- Authors
Zhang, Ning; Magland, Jeremy F; Rajapakse, Chamith S; Bhagat, Yusuf A; Wehrli, Felix W
- Abstract
Bone strength is the key factor impacting fracture risk. Assessment of bone strength from high-resolution (HR) images have largely relied on linear micro-finite element analysis (μFEA) even though failure always occurs beyond the yield point, which is outside the linear regime. Nonlinear μFEA may therefore be more informative in predicting failure behavior. However, existing nonlinear models applied to trabecular bone (TB) have largely been confined to micro-computed tomography (μCT) and, more recently, HR peripheral quantitative computed tomography (HR-pQCT) images, and typically have ignored evaluation of the post-yield behavior. The primary purpose of this work was threefold: (1) to provide an improved algorithm and program to assess TB yield as well as post-yield properties; (2) to explore the potential benefits of nonlinear μFEA beyond its linear counterpart; and (3) to assess the feasibility and practicality of performing nonlinear analysis on desktop computers on the basis of micro-magnetic resonance (μMR) images obtained in vivo in patients.
- Publication
Medical physics, 2013, Vol 40, Issue 5, p052303
- ISSN
2473-4209
- Publication type
Journal Article
- DOI
10.1118/1.4802085