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Title
Assessing operating characteristics of CAD algorithms in the absence of a gold standard.
Authors
Choudhury, Kingshuk Roy; Paik, David S; Yi, Chin A; Napel, Sandy; Roos, Justus; Rubin, Geoffrey D
Abstract
The authors examine potential bias when using a reference reader panel as "gold standard" for estimating operating characteristics of CAD algorithms for detecting lesions. As an alternative, the authors propose latent class analysis (LCA), which does not require an external gold standard to evaluate diagnostic accuracy.