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- Title
Fabrication of Nanoscale Bioarrays for the Study of Cytoskeletal Protein Binding Interactions Using Nanoimprint Lithography.
- Authors
Schvartzman, M; Nguyen, K; Palma, M; Abramson, J; Sable, J; Hone, J; Sheetz, M P; Wind, S J
- Abstract
We describe a high throughput patterning process used to create arrays of molecular-scale features for the study of cytoskeletal protein binding interactions. The process uses a shadow-evaporated metal mask to facilitate lift-off of features defined by nanoimprint lithography. This simple and robust approach alleviates difficulties in pattern transfer of ultra-small features and results in arrays of highly ordered sub-10 nm features which are then functionalized with extracellular matrix proteins. Application of these arrays is demonstrated in cell spreading assays.
- Publication
Journal of vacuum science & technology. B, Microelectronics and nanometer structures : processing, measurement, and phenomena : an official journal of the American Vacuum Society, 2009, Vol 27, Issue 1, p61
- ISSN
1071-1023
- Publication type
Journal Article
- DOI
10.1116/1.3043472