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- Title
Morphological, neurochemical and electrophysiological features of parvalbumin-expressing cells: a likely source of axo-axonic inputs in the mouse spinal dorsal horn.
- Authors
Hughes, D I; Sikander, S; Kinnon, C M; Boyle, K A; Watanabe, M; Callister, R J; Graham, B A
- Abstract
Perception of normal bodily sensations relies on the precise regulation of sensory information entering the dorsal horn of the spinal cord. Inhibitory, axoaxonic, synapses provide a mechanism for this regulation, but the source of these important inhibitory connections remains to be elucidated. This study shows that a subpopulation of spinal interneurons that expresses parvalbumin and have specific morphological, connectivity and functional characteristics are a likely source of the inhibitory inputs that selectivity regulate non-noxious tactile input in the spinal cord. Our findings suggest that a loss of normal function in parvalbumin positive dorsal horn neurons may result in the development of tactile allodynia, where non-painful stimuli gain the capacity to evoke the sensation of pain.
- Publication
The Journal of physiology, 2012, Vol 590, Issue 16, p3927
- ISSN
1469-7793
- Publication type
Journal Article
- DOI
10.1113/jphysiol.2012.235655