We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sexual dimorphism and oestrogen regulation of KCNE3 expression modulates the functional properties of KCNQ1 K<sup>+</sup> channels.
- Authors
Alzamora, Rodrigo; O'Mahony, Fiona; Bustos, Viviana; Rapetti-Mauss, Raphael; Urbach, Valérie; Cid, L. Pablo; Sepúlveda, Francisco V.; Harvey, Brian J.
- Abstract
Non-Technical Summary High levels of oestrogen are known to cause fluid retention in fertile females. It is thought that the increase in body fluid volume is necessary for proper implantation of the fertilised egg in the uterus. We show that the activity of a potassium ion channel, which drives salt and water movement across the cell membranes of the intestine, is inhibited by oestrogen and this effect is only found in females and is maximal during the peak phase of oestrogen in the oestrous cycle (when fertilization and implantation occur). These findings help us to understand the molecular mechanisms underlying the fluid retention effects of oestrogen in health and the potential adverse effects this response may have in exacerbating disease where fluid secretion is compromised such as in cystic fibrosis (the so-called CF 'gender gap').
- Publication
Journal of Physiology, 2011, Vol 589, Issue 21, p5091
- ISSN
0022-3751
- Publication type
Academic Journal
- DOI
10.1113/jphysiol.2011.215772