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- Title
O-glycosylation of the cardiac I<sub>Ks</sub> complex.
- Authors
Chandrasekhar, Kshama D.; Lvov, Anatoli; Terrenoire, Cecile; Gao, Grace Y.; Kass, Robert S.; Kobertz, William R.
- Abstract
Non-technical summary Post-translational modification of cardiac ion channels is a cellular mechanism for maintaining the rhythmicity of the heartbeat. We show that an essential regulatory subunit (KCNE1) of the cardiac IKs potassium channel complex is glycosylated at threonine-7 in vivo. Mutations that prevent glycosylation at this amino acid result in cardiac IKs complexes that are unable to efficiently traffic to the plasma membrane. These results provide a cellular mechanism for a KCNE1 mutation (T7I) that has been associated with cardiac arrhythmias.
- Publication
Journal of Physiology, 2011, Vol 589, Issue 15, p3721
- ISSN
0022-3751
- Publication type
Academic Journal
- DOI
10.1113/jphysiol.2011.211284