Title

The ubiquitous ATP molecule: could it be the elusive thermal mediator igniting skin perfusion and sweating in the heat-stressed human?

Authors

González‐Alonso, José; Kalsi, Kameljit K.

Abstract

The article explores the roles of nitric oxide synthase (NOS) and cyclooxygenase (COX) in the cutaneous vascular and sweating responses to intradermal administration of adenosine triphosphate (ATP) and the contribution of adenosine to ATP-induced skin vasodilatation. Topics discussed include the association of heat stress-induced hyperthermia with increases in intravascular ATP and the physiological relevance of interstitial ATP on thermal hyperaemia.

Subjects

PHYSIOLOGICAL effects of adenosine triphosphate; NITRIC-oxide synthases; CYCLOOXYGENASES; PERSPIRATION; PHYSIOLOGICAL effects of nucleotides; PHYSIOLOGICAL effects of phosphates

Publication

Journal of Physiology, 2015, Vol 593, Issue 11, p2399

ISSN

0022-3751

Publication type

Academic Journal

DOI

10.1113/JP270558