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- Title
In situ lung perfusion is a valuable tool to assess lungs from donation after circulatory death donors category I-II.
- Authors
Wauwer, Caroline; Munneke, Anita J.; Engels, Gerwin E.; Berga, Foke M.; Rakhorst, Gerhard; Nijsten, Maarten W.; Mariani, Massimo A.; Erasmus, Michiel E.
- Abstract
Donations after circulatory death ( DCD) lung grafts are an alternative to extend the donor pool in lung transplantation. This study investigates the use of an in situ lung perfusion system ( ISLP) in the donor to evaluate category I-II lungs. Pigs were sacrificed by ventricular fibrillation. All animals underwent 20 min of cardiopulmonary resuscitation and 5 min hands-off period after which heparin was administered. In group [ WI-1], this was followed by 1 h of warm ischemia ( WI) and 2 h of topical cooling ( TC). In group [ WI-2], 2 h of WI was followed by 1 h of TC. In group [ WI-0], there was a minimal period of WI and no TC. In all three groups, the lungs were then evaluated during 60 min with ISLP. [ WI-0] lungs showed a significantly higher compliance and Δ PO2/FiO2 compared with [ WI-1] and [ WI-2]. Pa CO2 and lactate production were higher in [ WI-2] versus [ WI-0]. Wet/Dry weight ratio was significantly higher in [ WI-2] compared with [ WI-0] in two lung biopsy locations. A high W/D weight ratio was correlated with a lower compliance, higher lactate production, and a higher Pa CO2. ISLP is an effective way to assess the quality of lungs from category I- II DCD donors.
- Publication
Transplant International, 2013, Vol 26, Issue 5, p485
- ISSN
0934-0874
- Publication type
Academic Journal
- DOI
10.1111/tri.12068