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- Title
Reduced intensity transplantation for congenital amegakaryocytic thrombocytopenia: report of a case and review of the literature.
- Authors
Woods, Gary; Bajwa, Rajinder P S; Rose, Melissa J
- Abstract
CAMT is a bone marrow failure syndrome that usually presents with isolated thrombocytopenia soon after birth. HSCT is curative, and MAC is associated with increased transplant-related morbidity and mortality, especially in the unrelated setting. We used a RIC regimen with alemtuzumab, fludarabine, and melphalan in a seven-month-old patient with CAMT who underwent a MUD HSCT. The transplant was well tolerated with few complications. Neutrophil and platelet engraftment occurred on day +12 and +29, respectively, and she had 100% donor chimerisms on days +19.
- Publication
Pediatric transplantation, 2014, Vol 18, Issue 1, pE31
- ISSN
1399-3046
- Publication type
Journal Article
- DOI
10.1111/petr.12175