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- Title
Successful allogeneic hemopoietic stem cell transplantation in a case of Wiskott-Aldrich syndrome and non-Hodgkin lymphoma.
- Authors
Tavil, Betul; Erdem, Arzu Yazal; Azik, Fatih; Isik, Pamir; Metin, Ayse; Emir, Suna; Uckan, Duygu; Tunc, Bahattin
- Abstract
WAS is a severe X-linked recessive disorder characterized by microthrombocytopenia, eczema, and immunodeficiency. A six-yr-old boy with WAS diagnosed as B-cell NHL (Stage III) localized in the liver who underwent successful HSCT from HLA-one antigen mismatch sibling donor has been presented here. His conditioning regimen included ATG, busulfan, and fludarabine. He received 2.3 × 10(6) /kg CD 34+ stem cells and 11 × 10(8) /kg nucleated cells at day 0. Neutrophil engraftment was achieved at day +14 and platelet engraftment at day +20. He has been in CR for more than two yr after transplantation. Thus, HSCT is an effective treatment for children with WAS even after development of lymphoma.
- Publication
Pediatric transplantation, 2013, Vol 17, Issue 6, pE146
- ISSN
1399-3046
- Publication type
Journal Article
- DOI
10.1111/petr.12114